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the space concerning the oxygen atom of Thr164 of Aph1 along with the oxygen atom of Tyr466 of PS1 is predicted being three.five Å, suggesting that a hydrogen bond (H...O distance, somewhere around 1.8 Å) is formed in these facet chains (Figure 7b). The T164A mutation might reduce the hydrogen bond with PS1 Y466, causing adaptable movement of your carboxy terminus of PS1. We suggest that Aph1 mutations control protease exercise through conformational adjustments in PS1.
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